Number of the records: 1
Componds derived from normuramyldipeptide
- 1.0487395 - ÚOCHB 2018 RIV eng P - Patent Document
Hipler, K. - Miller, A. - Turánek, J. - Ledvina, Miroslav
Componds derived from normuramyldipeptide.
2015. Owner: Imuthes Limited - Ústav organické chemie a biochemie AV ČR, v. v. i. - Výzkumný ústav veterinárního lékařství, v. v. i. Date of the patent acceptance: 15.04.2015. Patent Number: EP2578598
Institutional support: RVO:61388963
Keywords : normuramyl * glycopeptide compounds
OECD category: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2578598B1&KC=B1&FT=D&ND=4&date=20150415&DB=&locale=en_EP#
The invention provides a compound of Formula I wherein R 1 , R 4 and R 5 are each independently selected from hydrogen, acetyl, hydrocarbyl, R 2 is a hydrocarbyl, a lipid moiety, a lipid acyl moiety, or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety, R 8 is acetyl, X is a peptide chain, wherein hydrocarbyl is preferably acyl or alkyl, which can act as an adjuvant. The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen or DNA encoding the antigen, in vaccines, e.g., DNA vaccines.
Permanent Link: http://hdl.handle.net/11104/0282124
Number of the records: 1