Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review

0486688 - ÚŽFG 2018 RIV SE eng J - Journal Article
Hloušková, A. - Bielik, P. - Bonczek, O. - Balcar, V. J. - Šerý, Omar
Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review.
Neuroendocrinology Letters. Roč. 38, č. 3 (2017), s. 131-137. ISSN 0172-780X. E-ISSN 2354-4716
R&D Projects: GA MZd(CZ) NT11420
Institutional support: RVO:67985904
Keywords : hypodontia * oligodontia * Wnt signal pathway
OECD category: Dentistry, oral surgery and medicine
Impact factor: 0.754, year: 2017

AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.
Permanent Link: http://hdl.handle.net/11104/0281434