Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

0486290 - ÚMG 2018 RIV GB eng J - Journal Article
Gbelcová, H. - Rimpelová, S. - Knejzlík, Z. - Šáchová, Jana - Kolář, Michal - Strnad, Hynek - Repiska, V. - D'Acunto, C.W. - Ruml, T. - Vítek, L.
Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
Lipids in Health and Disease. Roč. 16, zima (2017), č. článku 250. E-ISSN 1476-511X
R&D Projects: GA MZd(CZ) NT13112
Institutional support: RVO:68378050
Keywords : Farmesyl pyrophosphate * Gene expression * Geranylgeranyl pyrophosphate * HMG-CoA reductase inhibitors * Isoprenoids * K-Ras oncogene * Mevalonate * Pncreatic cancer * Prenylation * Statins
OECD category: Cell biology
Impact factor: 2.663, year: 2017

Background: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in pancreatic cancer. In our study, we evaluated the effect of three key intermediates of the mevalonate pathway on GFP-K-Ras protein localization and the gene expression profile in pancreatic cancer cells after exposure to individual statins.
Permanent Link: http://hdl.handle.net/11104/0281151