Static high-gradient magnetic fields affect the functionality of monocytic cells

0486097 - FZÚ 2018 RIV US eng A1 - Journal Abstract
Syrovets, T. - Schmidt, Z. - Buechele, B. - Zablotskyy, Vitaliy A. - Dejneka, Alexandr - Dempsey, N. - Simmet, T.
Static high-gradient magnetic fields affect the functionality of monocytic cells.
FASEB JOURNAL. Roč. 28, č. 1 (2014), s. 1-2. ISSN 0892-6638. E-ISSN 1530-6860
Institutional support: RVO:68378271
Keywords : static high-gradient * magnetic fields * affect the functionality * monocytic cells
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)

Magnetic fields, different to electric fields, can intrude into deeper layers of tissue, where they could modulate biochemical processes. In this context, we explored the cellular effects of specifically designed high-performance micro-magnet arrays which, in contrast to conventional magnets, generate high-gradient magnetic fields not encountered in the environment. Exposure of monocytic cells to high-gradient magnetic fields of various strength generated by micro-magnet arrays induced cell swelling followed by accumulation of reactive oxygen species (ROS), and inhibition of cell proliferation. High levels of ROS may damage cellular structures and induce apoptosis. Consistently, prolonged exposure of cells to high-gradient magnetic fields induced time-dependent translocation of phosphatidylserine to the outer leaflet of the membrane.
Permanent Link: http://hdl.handle.net/11104/0280977