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Distinguishing glycan isomers by voltammetry. Modification of 2,3-sialyllactose and 2,6-sialyllactose by osmium(VI) complexes
- 1.0486056 - BFÚ 2018 RIV NL eng J - Journal Article
Trefulka, Mojmír - Paleček, Emil
Distinguishing glycan isomers by voltammetry. Modification of 2,3-sialyllactose and 2,6-sialyllactose by osmium(VI) complexes.
Electrochemistry Communications. Roč. 85, DEC2017 (2017), s. 19-22. ISSN 1388-2481. E-ISSN 1873-1902
R&D Projects: GA ČR(CZ) GA15-15479S
Institutional support: RVO:68081707
Keywords : prostate-specific antigen * maldi-tof-ms * os(vi)-modified polysaccharides
OECD category: Analytical chemistry
Impact factor: 4.660, year: 2017
Carbohydrate components in glycoproteins play a critical role in health and disease and specificity of glycoprotein biomarkers can be greatly enhanced by analysis of their sugar components containing frequently different isomers. We show that two glycan isomers, 2,3-sialyllactose and 2,6-sialyllactose (important in cancer), can be distinguished voltammetrically after their modification with osmium(VI) complexes. Using SWV at different frequencies and CV at different scan rates we found conditions for simple discrimination between these isomers at mercury and carbon electrodes.
Permanent Link: http://hdl.handle.net/11104/0280944
Number of the records: 1