Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate

0485880 - FGÚ 2018 RIV CH eng J - Journal Article
Kudláček, Jan - Chvojka, Jan - Pošusta, Antonín - Kováčová, Ľubica - Hong, S.B. - Weiss, S. - Volná, K. - Marusič, P. - Otáhal, Jakub - Jiruška, Přemysl
Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate.
Frontiers in Neurology. Roč. 8, Dec 21 (2017), č. článku 687. ISSN 1664-2295. E-ISSN 1664-2295
R&D Projects: GA ČR(CZ) GA14-02634S; GA ČR(CZ) GA15-08565S; GA MZd(CZ) NV15-29835A; GA MZd(CZ) NV17-28427A
Institutional support: RVO:67985823
Keywords : high-frequency oscillations * sharp-wave ripples * levetiracetam * lacosamide * antiepileptic drugs
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.508, year: 2017

Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.
Permanent Link: http://hdl.handle.net/11104/0280853