0485878 - FGÚ 2018 RIV US eng J - Journal Article
Rombaldová, Martina - Janovská, Petra - Kopecký, Jan - Kuda, Ondřej
Omega-3 fatty acids promote fatty acid utilization and production of pro-resolving lipid mediators in alternatively activated adipose tissue macrophages.
Biochemical and Biophysical Research Communications. Roč. 490, č. 3 (2017), s. 1080-1085. ISSN 0006-291X. E-ISSN 1090-2104
R&D Projects: GA ČR(CZ) GA16-05151S; GA MŠMT(CZ) LTAUSA17173
Institutional support: RVO:67985823
Keywords : adipose tissue * macrophages * omega-3 PUFA * fatty acid re-esterification * lipolysis * lipid mediators
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Impact factor: 2.559, year: 2017 ; AIS: 0.628, rok: 2017
DOI: https://doi.org/10.1016/j.bbrc.2017.06.170

It is becoming increasingly apparent that mutual interactions between adipocytes and immune cells are key to the integrated control of adipose tissue inflammation and lipid metabolism in obesity, but little is known about the non-inflammatory functions of adipose tissue macrophages (ATMs) and how they might be impacted by neighboring adipocytes. In the current study we used metabolipidomic analysis to examine the adaptations to lipid overload of M1 or M2 polarized macrophages co-incubated with adipocytes and explored potential benefits of omega-3 polyunsaturated fatty acids (PUFA). Macrophages adjust their metabolism to process excess lipids and M2 macrophages in turn modulate lipolysis and fatty acids (FA) re-esterification of adipocytes. While M1 macrophages tend to store surplus FA as triacylglycerols and cholesteryl esters in lipid droplets, M2 macrophages channel FA toward re-esterification and beta-oxidation. Dietary omega-3 PUFA enhance beta-oxidation in both M1 and M2. Our data document that ATMs contribute to lipid trafficking in adipose tissue and that omega-3 PUFA could modulate FA metabolism of ATMs.
Permanent Link: http://hdl.handle.net/11104/0280803