Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?

0485638 - BFÚ 2018 RIV CH eng J - Journal Article
Hofer, Michal - Hoferová, Zuzana - Falk, Martin
Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?
International Journal of Molecular Sciences. Roč. 18, č. 7 (2017). E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA16-12454S; GA MZd NV16-29835A
Institutional support: RVO:68081707
Keywords : acute radiation syndrome * radioprotectors * radiomitigators
OECD category: Biochemistry and molecular biology
Impact factor: 3.687, year: 2017

In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider beta-glucan, 5-AED (5-androstenediol), meloxicam, gamma-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl) adenosine-5'-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.
Permanent Link: http://hdl.handle.net/11104/0280598