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A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts
- 1.0485197 - BC 2018 RIV US eng J - Journal Article
Ishemgulova, A. - Kraeva, N. - Hlaváčová, J. - Zimmer, S.L. - Butenko, A. - Podešvová, L. - Leštinová, T. - Lukeš, Julius - Kostygov, A. - Votýpka, Jan - Volf, P. - Yurchenko, V.
A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts.
PLoS Neglected Tropical Diseases. Roč. 11, č. 7 (2017), č. článku e0005782. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA MŠMT LL1601
Institutional support: RVO:60077344
Keywords : multiple sequence alignment * sand flies * trypanosoma-brucei * expression system * p-loop * transmission * evolution * parasites * resource * kinases
OECD category: Biochemistry and molecular biology
Impact factor: 4.367, year: 2017
Leishmania virulence factors responsible for the complicated epidemiology of the various leishmaniases remain mainly unidentified. This study is a characterization of a gene previously identified as upregulated in two of three overlapping datasets containing putative factors important for Leishmania's ability to establish mammalian intracellular infection and to colonize the gut of an insect vector.
Permanent Link: http://hdl.handle.net/11104/0280366
Number of the records: 1