Role of silica nanoparticles in monitoring and prolonging release of drug-eluting polyelectrolyte coatings using long-period fiber grating platform

0484862 - ÚFE 2018 RIV CH eng J - Journal Article
Tian, F. - Kaňka, Jiří - Yang, F. - Min, J. - Hammond, P. T.
Role of silica nanoparticles in monitoring and prolonging release of drug-eluting polyelectrolyte coatings using long-period fiber grating platform.
Sensors and Actuators B - Chemical. Roč. 252, November (2017), s. 831-839. E-ISSN 0925-4005
R&D Projects: GA ČR(CZ) GBP205/12/G118
Institutional support: RVO:67985882
Keywords : Long period gratings * Sensor * Layer-by-layer assembly
OECD category: Electrical and electronic engineering
Impact factor: 5.667, year: 2017

ilica nanoparticles (SNPs) were synergistically integrated with long-period grating (LPG) platform and the process of layer-by-layer (LbL) assembly to enable monitoring controlled release of drug-eluting polyelectrolyte coatings. The SNPs afforded a high surface area for increased drug loading as well as enhanced evanescent field overlap. In addition, the SNPs positioned within the LbL coatings acted as diffusion barrier layer, leading to prolonged release profile. SNPs with different sizes were respectively immobilized on the LPG using poly allylamine hydrochloride (PAH). In-situ monitoring of drug-eluting LbL coating [chitosan (CHI)/Poly arylic acid (PAA)/Gentamicin sulfate (GS)PAA](n), was carried out on LPG with a sensitivity of 8.1 nm shift/tetralayer for LPG with 1 layer of SNPs with 50 nm in diameter. LPG without the SNPs for the monitoring of [CHI/PAA/GS/PAA](n) shows a sensitivity of 2.4 nm shift/tetralayer, indicating the significant ability of SNPs in enhancing the LPG sensitivity. Drug release measurement carried out on the LPG platform revealed an increased release time for LbL-SNP drug delivery system compared with that of LbL alone
Permanent Link: http://hdl.handle.net/11104/0279991