Phthalocyanine-conjugated upconversion NaYF4:Yb3+/Er3+@SiO2 nanospheres for NIR-triggered photodynamic therapy in a tumor mouse model

0483483 - ÚMCH 2018 RIV DE eng J - Journal Article
Kostiv, Uliana - Patsula, Vitalii - Noculak, A. - Podhorodecki, A. - Větvička, D. - Poučková, P. - Sedláková, Zdeňka - Horák, Daniel
Phthalocyanine-conjugated upconversion NaYF4:Yb3+/Er3+@SiO2 nanospheres for NIR-triggered photodynamic therapy in a tumor mouse model.
ChemMedChem. Roč. 12, Issue 24 (2017), s. 2066-2073. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR(CZ) GA15-01897S
Institutional support: RVO:61389013
Keywords : upconversion nanospheres * phthalocyanine * photodynamic therapy
OECD category: Polymer science
Impact factor: 3.009, year: 2017

Photodynamic therapy (PDT) has garnered immense attention as a minimally invasive clinical treatment modality for malignant cancers. However, its low penetration depth and photodamage of living tissues by UV and visible light, which activate a photosensitizer, limit the application of PDT. In this study, monodisperse NaYF4:Yb3+/Er3+ nanospheres 20 nm in diameter, that serve as near-infrared (NIR)-to-visible light converters and activators of a photosensitizer, were synthesized by high-temperature co-precipitation of lanthanide chlorides in a high-boiling organic solvent (octadec-1-ene). The results demonstrate that the NaYF4:Yb3+/Er3+@SiO2-PEI-Pc-PEG nanospheres have great potential as a novel NIR-triggered PDT nanoplatform for deep-tissue cancer therapy.
Permanent Link: http://hdl.handle.net/11104/0279476