Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

0483285 - ÚMG 2018 RIV GB eng J - Journal Article
Klein, O. - Ngo-Nyekel, F. - Stefanache, T. - Torres, R. - Salomonsson, M. - Hallgren, J. - Radinger, M. - Bambousková, Monika - Campbell, M. - Cohen-Mor, S. - Dema, B. - Rose, C.G. - Abrink, M. - Charles, N. - Ainooson, G. - Paivandy, A. - Pavlova, V.G. - Serrano-Candelas, E. - Yu, Y. - Hellman, L. - Jensen, B.M. - Van Anrooij, B. - Grootens, J. - Gura, H.K. - Stylianou, M. - Tobio, A. - Blank, U. - Ohrvik, H. - Maurer, M.
Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets.
Scandinavian Journal of Immunology. Roč. 83, č. 6 (2016), s. 465-472. ISSN 0300-9475. E-ISSN 1365-3083
Institutional support: RVO:68378050
Keywords : tyrosine kinase inhibitors * fc-epsilon-ri * in-vivo * inflammatory diseases * dependent activation * midostaurin pkc412 * mediator release * murine basophils * animal-models * mouse models
OECD category: Immunology
Impact factor: 2.256, year: 2016

In this letter to editor, 20 students and eight trainers from 11 countries all across Europe met at the two-day training school action held in Uppsala, Sweden. In the frame of the COST Action BM1007 “Mast cells and basophils - Target for Innovative Therapies they discussed various aspects of mast cells physiology. The topics summarized in the letter involved (1) mast cell and basophil development in vivo and in vitro (2) mast cell- and basophil-deficient mouse, (3) the difference between human and mouse mast cells and basophil, and (4) are tyrosine kinase inhibitors potential targets for mast cell- and basophil-driven diseases? The combined data show accumulated knowledge about mast cell and basophils physiology and suggest new possibilities to treat mast cell- and basophil-mediated diseases.
Permanent Link: http://hdl.handle.net/11104/0281310