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Controlling complexity: the clinical relevance of mouse complex genetics
- 1.0483191 - ÚMG 2018 RIV GB eng J - Journal Article
Forejt, Jiří … Total 50 authors
Controlling complexity: the clinical relevance of mouse complex genetics.
European Journal of Human Genetics. Roč. 21, č. 11 (2013), s. 1191-1196. ISSN 1018-4813. E-ISSN 1476-5438
Institutional support: RVO:68378050
Keywords : Mouse model * Forward genetics * Rewiev
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 4.225, year: 2013
Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
Permanent Link: http://hdl.handle.net/11104/0278582
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