Oocytes

0483024 - ÚŽFG 2018 RIV AT eng M - Monography Chapter
Šušor, Andrej - Kubelka, Michal
Translational regulation in the mammalian oocyte.
Oocytes. Wien: Springer International Publishing, 2017, s. 257-295. ISBN 978-3-319-60855-6
R&D Projects: GA ČR GA13-12291S; GA ČR GA15-22765S; GA MŠMT EF15_003/0000460
Institutional support: RVO:67985904
Keywords : mammalian oocyte
OECD category: Biochemistry and molecular biology

Fully grown oocytes arrest meiosis at prophase I and deposit maternal RNAs. A subset of maternal transcripts is stored in a dormant state in the oocyte, and the timely driven translation of specific mRNAs guides meiotic progression, the oocyte-embryo transition, and early embryo development. In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization and at the level of protein synthesis. This chapter focuses on the recent findings on RNA distribution related to the temporal and spatial translational control of the meiotic cycle progression in mammalian oocytes. We discuss the most relevant mechanisms involved in the organization of the oocyte’s maternal transcriptome storage and localization, and the regulation of translation, in correlation with the regulation of oocyte meiotic progression.
Permanent Link: http://hdl.handle.net/11104/0278448