The role of nitric oxide during embryonic epidermis development of Xenopus laevis

0482593 - BTÚ 2018 RIV GB eng J - Journal Article
Tománková, Silvie - Abaffy, Pavel - Šindelka, Radek
The role of nitric oxide during embryonic epidermis development of Xenopus laevis.
Biology Open. Roč. 6, č. 6 (2017), s. 862-871. ISSN 2046-6390. E-ISSN 2046-6390
R&D Projects: GA MŠMT LK21305; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LH15074
Institutional support: RVO:86652036
Keywords : Development * Nitric oxide * Epidermis * Xenopus laevis
OECD category: Developmental biology
Impact factor: 2.217, year: 2017

Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development.
Permanent Link: http://hdl.handle.net/11104/0278135