Relay feedback oscillator design for modeling circadian rhythms in cyanobacteria

0482418 - ÚVGZ 2019 RIV US eng C - Conference Paper (international conference)
Fišer, J. - Zítek, P. - Červený, Jan
Relay feedback oscillator design for modeling circadian rhythms in cyanobacteria.
PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2011. Vol. 2. Denver, Colorado: ASME, 2012, s. 549-556. ISBN 978-0-7918-5488-4.
[ASME International Mechanical Engineering Congress and Exposition (IMECE). Denver (US), 11.11.2011-17.11.2011]
Institutional support: RVO:86652079
Keywords : biological rhythms * mathematical-model * control-systems * clock * phosphorylation * neurospora * drosophila * protein * period * light * circadian rhythms * oscillator * limit cycle * relay characteristics * cyanobacteria growth
OECD category: Nano-materials (production and properties)

The paper introduces a relay feedback oscillator for modeling circadian rhythms in cyanobacteria. The relay feedback oscillator is equipped with low pass filter F(j omega), hysteresis-type relay and negative feedback. This negative feedback represents an autoregulatory mechanism of the circadian clock and the notion of this autoregulatory mechanism is based on the well-known Goodwin biochemical oscillator [1]. The relay is responsible for the mediation of both the activation and degradation of oscillator state variables (protein concentrations) and in this way the pacemaker is constituted. Later on, low pass filter poles are identified for the purpose of modeling auto-oscillations with the free running period of 24h and the method of the pole identification consists in an ultimate frequency test providing stability margin of a single-loop composed of the filter and the relay in the feedback. Next, a relay output / input ratio of amplitudes and hysteresis are found out by the graphical test of the single-loop on the stability margin which is carried out in Bode graph. Finally, the output correspondence of relay feedback oscillator model with Miyoshi oscillator [2] is provided because the Miyoshi oscillator is well recognized among biochemical oscillators for species of cyanobacteria.
Permanent Link: http://hdl.handle.net/11104/0277826