Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

0482106 - MBÚ 2018 RIV CH eng J - Journal Article
Fedele, G. - Schiavoni, O. - Adkins, I. - Klímová, Nela - Šebo, Peter
Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.
Toxins. Roč. 9, č. 10 (2017), s. 1-15, č. článku 293. ISSN 2072-6651. E-ISSN 2072-6651
R&D Projects: GA MZd(CZ) NV16-28126A; GA ČR(CZ) GA13-14547S; GA MŠMT(CZ) LM2015064
Institutional support: RVO:61388971
Keywords : immune response * intracellular pathways * phagocytosis
OECD category: Other biological topics
Impact factor: 3.273, year: 2017

Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host's respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3,5-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells. CyaA-induced cAMP signaling swiftly incapacitates opsonophagocytosis, oxidative burst and NO-mediated killing of bacteria by neutrophils and macrophages. The subversion of host immune responses by CyaA after delivery into DC, macrophages and neutrophils is the subject of this review.
Permanent Link: http://hdl.handle.net/11104/0277522