The deposition of inhaled manganese nanoparticles in mice organs

0481652 - ÚIACH 2018 IE eng A - Abstract
Machala, M. - Kulich, P. - Šerý, Omar - Dočekal, Bohumil - Večeřa, Zbyněk - Zeman, T. - Míšek, Ivan
The deposition of inhaled manganese nanoparticles in mice organs.
Toxicology Letters. Elsevier. Roč. 238, č. 2 (2015), s. 206-206. ISSN 0378-4274. E-ISSN 1879-3169.
[Congress of the European Societies of Toxicology (EUROTOX) /51./. 13.09.2015-16.09.2015, Porto]
R&D Projects: GA ČR(CZ) GBP503/12/G147
Institutional support: RVO:68081715 ; RVO:67985904
Keywords : nanoparticles * manganese oxide * inhalation chamber * mice
Subject RIV: CB - Analytical Chemistry, Separation

Biokinetics of manganese oxide (MnO·Mn2O3) nanoparticles (NPs) was studied in male ICR mice after 17-week exposure in inhalation chamber by transmission electron microscopy (TEM), scan electron microscopy (SEM) and electrothermal atomic absorption spectrometry (ET-AAS) analyses. The study focused on the distribution of Mn NPs in selected tissues (lung, erythrocytes, liver, spleen, brain). First, uniformity, shape and size of NPs, used for exposure inhalation experiments, were characterized by TEM. The NP size was on average 20nm (9–35 nm), and they mostly polygonal shape.
Permanent Link: http://hdl.handle.net/11104/0277177