Microbiota and selected lactobacilli strains sustain mouse juvenile growth dynamics upon undernutrition

0479971 - MBÚ 2018 eng A - Abstract
Schwarzer, Martin - Kassem, M. - Storelli, G. - Machuta-Gayet, I. - Šrůtková, Dagmar - Hermanová, Petra - Martino Maria Elena, M.E. - Balmand, S. - Hudcovic, Tomáš - Heddi, A. - Rieusset, J. - Kozáková, Hana - Vidal, H. - Leulier, F.
Microbiota and selected lactobacilli strains sustain mouse juvenile growth dynamics upon undernutrition.
Food, Microbiota and Immunity „For strong immunity – feed your microbiota well“. Praha: Czech immunological society, 2017. s. 10-10.
[Food, Microbiota and Immunity. 07.06.2017-10.06.2017, Třešť]
R&D Projects: GA ČR GA15-07268S
Institutional support: RVO:61388971
Keywords : Lactobacillus * juvenile growth * undernutrition
OECD category: Immunology

In most animal species, juvenile growth is characterized by an exponential gain in body weight and size. In our study we have show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet.We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.
Permanent Link: http://hdl.handle.net/11104/0275953