Effect of inhaled PbO nanoparticles on mice organs after long-term exposition

0478363 - ÚIACH 2018 CH eng A - Abstract
Mikuška, Pavel - Večeřa, Zbyněk - Buchtová, Marcela - Dumková, J. - Putnová, Barbora - Dočekal, Bohumil - Čapka, Lukáš - Coufalík, Pavel - Křůmal, Kamil - Fictum, P. - Hampl, A.
Effect of inhaled PbO nanoparticles on mice organs after long-term exposition.
Program. European Aerosol Conference 2017. 2017. T409N27a. ISBN N.
[European Aerosol Conference EAC2017. 27.08.2017-01.09.2017, Zurich]
R&D Projects: GA ČR(CZ) GBP503/12/G147
Institutional support: RVO:68081715
Keywords : nanoparticles * lead oxide * toxicity
Subject RIV: CB - Analytical Chemistry, Separation; EB - Genetics ; Molecular Biology (UZFG-Y)
http://www.gaef.de/EAC2017/

Contribution summarizes findings obtained during inhalation experiments performed with mice for 6 weeks. Inhalation of PbO nanoparticles results in their accumulation not only in the organ of entry, the lungs, but they were also transported by blood to other organs causing serious damage at tissue as well as at cellular level. The exposure to high doses of such nanoparticles leads to complex symptoms affecting the entire body.
Permanent Link: http://hdl.handle.net/11104/0274464