Positive and Negative Signals in Mast Cell Activation

0477931 - ÚMG 2018 RIV GB eng J - Journal Article
Bulfone-Paus, S. - Nilsson, G. - Dráber, Petr - Blank, U. - Levi-Schaffer, F.
Positive and Negative Signals in Mast Cell Activation.
Trends in Immunology. Roč. 38, č. 9 (2017), s. 657-667. ISSN 1471-4906. E-ISSN 1471-4981
Institutional support: RVO:68378050
Keywords : fc-epsilon-ri * receptor irp60 cd300a * inhibitory receptor * inflammatory responses * allergic reactions * tetraspanin cd9 * human basophils * ige repertoire * host-defense * in-vitro
OECD category: Immunology
Impact factor: 14.188, year: 2017

Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel Fc epsilon RI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors.
Permanent Link: http://hdl.handle.net/11104/0274143