DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas

0477879 - ÚMG 2018 RIV GB eng J - Journal Article
Benešová, Martina - Trejbalová, Kateřina - Kovářová, Denisa - Vernerová, Z. - Hron, Tomáš - Kučerová, Dana - Hejnar, Jiří
DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas.
Retrovirology. Roč. 14, č. 1 (2017), č. článku 20. E-ISSN 1742-4690
R&D Projects: GA ČR GA13-37600S; GA MZd NT14601
Institutional support: RVO:68378050
Keywords : Human endogenous retrovirus * ERVWE1 * Germ cell tumor * Seminoma * Promoter DNA methylation * 5-Hydroxymethylcytosine * Transcription * RNA splicing
OECD category: Virology
Impact factor: 3.417, year: 2017

Background: Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotrophoblast in chorionic villi. In non-trophoblastic cells, however, the expression of syncytins has to be suppressed to avoid potential pathogenic effects. Previously, we have shown that the transcriptional suppression of ERVWE1 promoter is controlled epigenetically by DNA methylation and chromatin modifications. In this study, we describe the aberrant expression of syncytin-1 in biopsies of testicular germ cell tumors.
Permanent Link: http://hdl.handle.net/11104/0274098