0477601 - BÚ 2018 RIV US eng J - Journal Article
Salmina, K. - Huna, A. - Inashkina, I. - Belyayev, Alexander - Krigerts, J. - Paštová, Ladislava - Vazquez-Martin, A. - Erenpreisa, J.
Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.
Nucleus. Roč. 8, č. 2 (2017), s. 205-221. ISSN 1949-1034. E-ISSN 1949-1042
Institutional support: RVO:67985939
Keywords : aggresome * ALU retrotransposition * autophagy
OECD category: Cell biology
Impact factor: 2.210, year: 2017

As an origin of heterochromatin fragmentation, the unscheduled DNA synthesis and circular DNAs were found in the perinucleolar heterochromatin shell, along with activation and retrotransposition of ALU elements, colocalised with 45S rDNA in NoAs. The data indicate coordination of the basic nucleolar function with autophagy regulation in maintenance of the integrity of the nucleolus associated domains secured by inactivity of retrotransposons.
Permanent Link: http://hdl.handle.net/11104/0277194