Qualitative analyses of less-volatile organic molecules from female skin scents by comprehensive two dimensional gas chromatography-time of flight mass spectrometry

0477082 - ÚOCHB 2018 RIV NL eng J - Journal Article
Doležal, P. - Kyjaková, Pavlína - Valterová, Irena - Urban, Š.
Qualitative analyses of less-volatile organic molecules from female skin scents by comprehensive two dimensional gas chromatography-time of flight mass spectrometry.
Journal of Chromatography A. Roč. 1505, Jul 7 (2017), s. 77-86. ISSN 0021-9673. E-ISSN 1873-3778.
[International Symposium on Capillary Chromatography /40./ and GCxGC Symposium /13./. Riva del Garda, 29.05.2016-03.06.2016]
Institutional support: RVO:61388963
Keywords : human scent analysis * molecular composition of human scent * forensic chemistry * human scent signature * GCxGC-TOFMS
OECD category: Analytical chemistry
Impact factor: 3.716, year: 2017

Instrumental human scent analysis is undoubtedly desirable for many forensic as well medical applications. Most of the previous human scent studies were focused on volatile organic compounds (VOCs) which were analysed by head space solid phase micro-extraction gas chromatography/mass spectrometry (HS-SPME-GC/MS). This method is, however, significantly less sensitive to ”heavier” less volatile compounds emitted from the human skin. These less volatile organic scent molecules probably create the basis of the individual human scent signature, and therefore, our attention is focused mainly on these ”heavier” compounds. The human scent was adsorbed onto purified glass beads and samples were prepared as hexane solutions obtained by extraction from the sampled glass beads. To resolve a lot of very similar molecules, the comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometer (GCxGC-TOFMS) was used to analyse the hexane scent solutions. Using this technique, more than 137 less volatile molecules including organic fatty acids, ketones, aldehydes, simple esters, alcohols, and especially various fatty acid esters with different carbon chains were identified. A considerable number of these molecules were identified in the scent samples for the first time.
Permanent Link: http://hdl.handle.net/11104/0273482