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O 17 - MiR137 and the production of mucin: a potential tool in early diagnosis of colorectal cancer
- 1.0475775 - ÚEM 2017 RIV eng C - Conference Paper (international conference)
Bártů, Linda - Svoboda, M. - Korenková, Vlasta - Slyšková, J. - Langerová, Lucie - Schneiderová, M. - Levý, M. - Vodička, Pavel
O 17 - MiR137 and the production of mucin: a potential tool in early diagnosis of colorectal cancer.
44th Annual Meeting EEMGS 2015. 2015, s. 114-114.
[Annual Meeting European Environmental Mutagenesis and Genomics Society /44./. Prague (CZ), 23.08.2015-26.08.2015]
R&D Projects: GA MZd(CZ) NT13424; GA ČR(CZ) GA15-14789S; GA MŠMT(CZ) LH13061
Institutional support: RVO:68378041
Keywords : colon cancer * mucins * mUC13 * miRNA * prognosis
Subject RIV: EB - Genetics ; Molecular Biology; EB - Genetics ; Molecular Biology (BTO-N)
Mucins are glycoproteins in the bowel responsible for lubrication and antimicrobial defence. Altered mucin expression emerges as a feature of precancerous and cancer cell. The aim of our study was to investigate mechanisms of action of several distinct glycoproteins. Our findings support concept of proinflamatory and tumour promoting role of overexpressed MUC13 in CRC, while downregulation is associated with potentially less harmful genetic imprint and may influence the disease prognosis.
Permanent Link: http://hdl.handle.net/11104/0272414
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