Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic

0475711 - ÚEB 2018 RIV GB eng J - Journal Article
Maršík, Petr - Rezek, Jan - Židková, Monika - Kramulová, Barbora - Tauchen, J. - Vaněk, Tomáš
Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic.
Chemosphere. Roč. 171, MAR (2017), s. 97-105. ISSN 0045-6535. E-ISSN 1879-1298
R&D Projects: GA ČR(CZ) GA14-22593S
Grant - others:European Regional Development Fund(XE) CZ.2.16/3.1.00/24014; European Regional Development Fund(XE) CZ.2.16/3.1.00/21519
Institutional support: RVO:61389030
Keywords : chromatography-mass-spectrometry * gas-chromatography * human pharmaceuticals * waste-water * surface-water * risk-assessment * diclofenac * ibuprofen * products * plants * NSAID Surface water * Pharmaceuticals * GCxGC-TOFMS Elbe basin * Czech Republic
OECD category: Environmental biotechnology
Impact factor: 4.427, year: 2017

Non-steroidal anti-inflammatory drugs (NSAIDs) belong to most used pharmaceuticals in the human and veterinary medicine. The widespread consumption of NSAIDs has led to their ubiquitous occurrence in water environment including large river systems. In the present study, concentrations of the five most frequently used NSAIDs (ibuprofen, diclofenac, naproxen, ketoprofen and indomethacin) were determined in the watercourses of the river Elbe basin in Czech Republic. The presence of the pharmaceuticals was measured at 29 sampling sites including urban and rural areas, small creeks and main tributaries of the Elbe monthly from April to December of 2011. For the NSAIDs quantitation, the comprehensive analytical method combing pentafluorobenzyl bromide (PFBBr) derivatization with highly sensitive twodimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS) was developed. Although the content of all NSAIDs varied at the particular sampling points significantly, total amount of particular compounds was relatively stable during all monitored periods with only non-significant increase in the spring and autumnal months. Ibuprofen was found to be the most abundant drug with maximum concentration of 3210 ng/L, followed by naproxen, diclofenac and ketoprofen (1423.8 ng/L, 1080 ng/L and 929.8 ng/L, respectively). Indomethacin was found only at several sampling sites (maximum concentration of 693 ng/L). Concentrations of all compounds except ibuprofen were significantly higher at sampling sites with low flow rates (creeks), followed by the biggest watercourses.
Permanent Link: http://hdl.handle.net/11104/0272357