Chromosomal damage as markers of genotoxic effect and carcinogenesis

0475586 - ÚEM 2017 RIV CZ eng A - Abstract
Vodička, Pavel - Polívková, Z. - Mušák, L. - Dušinská, M. - Vodenková, Soňa - Vymetálková, Veronika - Kroupa, Michal - Vodičková, Ludmila - Demová, H. - Poláková, Veronika - Ambruš, M. - Kumar, R. - Hemminki, K.
Chromosomal damage as markers of genotoxic effect and carcinogenesis.
Prague Medical Report. Nakladatelství Karolinum. Roč. 116, č. 2015 (2015), s. 56-63. ISSN 1214-6994.
[15th Central European Lung Cancer Conference including Best of WCLC 2015. 28.11.2015-30.11.2015, Praha]
R&D Projects: GA ČR(CZ) GAP304/12/1585; GA ČR(CZ) GA15-14789S; GA MZd(CZ) NT14329; GA MZd(CZ) NT14056; GA MŠMT LH13061; GA MŠMT(CZ) LD14050
Institutional support: RVO:68378041
Keywords : chromosomal aberrations * malignant transformation * incident cancer patients * cancer risk * CIN * DNA repair
Subject RIV: EB - Genetics ; Molecular Biology

Many cancers often arise from cells unable to maintain genomic and chromosomal instability. Recurrent chromosomal aberrations (CAs) arise through a clonal growth of cells with specific translocations, deletions or amplifications of chromosomal regions or whole chromosomes and many specific CAs are causative events in malignant transformation. In our studies we compared frequencies of CAs in patients with incident lung, breast and colorectal cancer. Additionally, we have also searched for genetic background that modulates chromosomal instability in humans. The DNA repair characteristics have been discussed as well.
Permanent Link: http://hdl.handle.net/11104/0272291