0475050 - ÚOCHB 2018 RIV GB eng J - Journal Article
Neburková, Jitka - Vávra, Jan - Cígler, Petr
Coating nanodiamonds with biocompatible shells for applications in biology and medicine.
Current Opinion in Solid State & Materials Science. Roč. 21, č. 1 (2017), s. 43-53. ISSN 1359-0286. E-ISSN 1879-0348
R&D Projects: GA ČR(CZ) GA16-16336S; GA MZd(CZ) NV15-33094A; GA MŠMT(CZ) 7AMB16FR029
Institutional support: RVO:61388963
Keywords : polymer * core-shell * antifouling
OECD category: Polymer science
Impact factor: 6.548, year: 2017 ; AIS: 2.21, rok: 2017
DOI: https://doi.org/10.1016/j.cossms.2016.05.008

Use of nanodiamonds (NDs) as nontoxic nanoparticles for biological imaging, sensing, and drug delivery is expanding rapidly. The interest in NDs is triggered by their unique combination of optical properties. ND can accommodate nitrogen-vacancy color centers which provide stable fluorescence without photo bleaching or photoblinking and their electronic structure is very sensitive to magnetic and electric fields. The limited options to control ND properties during synthesis or by direct surface functionalization leave room to be improved upon by employing surface coatings engineered precisely for a particular application. The major disadvantages of unmodified NDs are their limited colloidal stability and tendency to non-specifically adsorb biomolecules. This review aims to summarize recent advances in coating NDs (namely with silica and polymer shells), which addresses these disadvantages and enables the use of NDs in biological applications such as targeting of specific cells, drug delivery, and biological imaging.
Permanent Link: http://hdl.handle.net/11104/0271928