Maternal and paternal influences in the transmission of diabetes – induced changes.\n

0474838 - BTÚ 2018 CZ eng A - Abstract
Pavlínková, Gabriela - Valášková, Eliška - Žatecká, Eva - Bohuslavová, Romana - Elzeinová, Fatima - Margaryan, Hasmik - Pěknicová, Jana
Maternal and paternal influences in the transmission of diabetes – induced changes.
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Book of abstracts XXIIIrd Symposium of Immunology and Biology of Reproduction. Vestec u Prahy: Biotechnologický ústav AVČR v. v. i., 2017 - (Kubátová, a.). s. 18-18
[XXIIIrd Symposium of Immunology and Biology of Reproduction. 18.05.2017-20.05.2017, Třešť]
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA MZd(CZ) AZV 15-30880A
Institutional support: RVO:86652036
Keywords : diabetes mellitus * transgenerational transmission * reproduction * metabolic health
OECD category: Endocrinology and metabolism (including diabetes, hormones)

Clinical and experimental studies demonstrate that the exposure to diabetic environment, can increase susceptibility for diabetes in the offspring and that both maternal and paternal factors contribute to offspring phenotypes.
Diabetic pregnancy has been associated with higher risk of adverse outcomes, such as perinatal mortality and congenital birth defects, compared to non-diabetic pregnancy. In addition to direct teratogenicity of maternal diabetes, the intrauterine and early postnatal environment can influence cardiovascular and metabolic health of offspring later in life. This phenomenon is also termed fetal or developmental programming. The offspring of diabetic pregnancy show differences in metabolic, cardiovascular and inflammatory variables compared to the offspring of non-diabetic mothers.
Additionally, a number of recent studies show transgenerational transmission of metabolic phenotypes from males to their offspring. We focused our studies on the effects of diabetes on the male reproductive system in type 1 diabetes model. We showed that direct exposure to the diabetic environment negatively affects the testis morphology, sperm viability, sperm concentration, and sperm characteristics. Additionally, paternal diabetes induces unfavourable changes in the subsequent F1 and F2 offspring generations and thus, an increased risk for infertility disorders in the offspring. Our data are in line with other studies calling for new strategies to improve metabolic health not only in women of reproductive age but also in potential fathers in order to reduce susceptibility to diabetes and related pathologies in subsequent generations.




Permanent Link: http://hdl.handle.net/11104/0276732