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Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles

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    0474727 - ÚMCH 2018 RIV US eng C - Conference Paper (international conference)
    Horák, Daniel - Kostiv, Uliana - Proks, Vladimír - Jirák, D.
    Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles.
    TechConnect Briefs 2017. Danville: TechConnect, 2017, s. 114-117. ISBN 978-0-9988782-0-1.
    [TechConnect World Innovation Conference & Expo. Nanotech 2017. Washington (US), 14.05.2017-17.05.2017]
    R&D Projects: GA ČR(CZ) GA15-01897S
    Institutional support: RVO:61389013
    Keywords : upconversion * magnetic * nanoparticles
    OECD category: Polymer science
    https://briefs.techconnect.org/papers/carcinoma-cellular-uptake-imaging-and-targeting-by-rgds-and-tat-conjugated-upconversion-and-or-magnetic-nanoparticles/

    We have developed monodisperse magnetic Fe3O4, upconversion NaYF4:Yb3+/Er3+, and dual paramagnetic/upconversion NaGdF4: Yb3+/Er3+ nanoparticles with tunable size by thermal decomposition of Fe(III) oleate and lanthanide chlorides in high-boiling organic solvents. Aminosilica and 4-pentynoic acid were then introduced on the particle surface to conjugate the cell adhesive and cell penetrating RGD and TAT peptides, respectively. Optionally, NaYF4:Yb3+/Er3+@SiO2-NH2 particles reacted with methoxyPEG succinimidyl ester to diminish uptake of the particles by the reticulo-endothelial system. Neural stem cell viability and labeling efficiency of the particles were determined. Al carboxyphthalocyanine was conjugated to NaYF4:Yb37Er3+@SiO2-PEG nanoparticles, which were intravenously administered in athymic nude mice with xenotransplanted human prostate carcinoma PC-3. After NIR photodynamic therapy, the tumor subsided and its volume approached to zero.
    Permanent Link: http://hdl.handle.net/11104/0280742

     
     
Number of the records: 1  

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