Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite

0474348 - BC 2018 RIV US eng J - Journal Article
Mateos-Hernández, L. - Villar, M. - Moral, A. - Garcia Rodriguez, C. - Alfaya Arias, T. - de la Osa, V. - Feo Brito, F. - Fernández de Mera, I.G. - Alberdi, P. - Ruiz-Fons, F. - Cabezas Cruz, Alejandro - Estrada-Peňa, A. - de la Fuente, J.
Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite.
OncoTarget. Roč. 8, č. 13 (2017), s. 20630-20644. ISSN 1949-2553
EU Projects: European Commission(XE) 278976 - ANTIGONE
Institutional support: RVO:60077344
Keywords : immunology * allergy * alpha-Gal * anaphylaxis * proteomics * immunology and microbiology section * immune response * immunity
OECD category: Immunology
Impact factor: 5.168, year: 2016

Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate alpha-Gal (Gal alpha 1-3Gal beta 1-(3) 4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. To address this question, a comparative proteomics approach was used to characterize tick proteins producing an IgE antibody response in a healthy individual with record of tick bites, which had not resulted in any allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus bursa or Hyalomma marginatum tick bites. Both patients and the healthy individual were red meat tolerant. The results supported a patient-specific IgE antibody response to tick species responsible for the anaphylaxis to tick bite. Both patients and the healthy individual serologically recognized tick proteins with and without alpha-Gal modifications, with proteins differentially recognized by patients but not control sera. These proteins could be used as potential antigens for diagnostics, treatment and prevention of tick bite-induced allergies.
Permanent Link: http://hdl.handle.net/11104/0275155