Relapse in Schizophrenia: Definitively not a Bolt from the Blue

0473672 - ÚI 2019 RIV IE eng J - Journal Article
Španiel, F. - Bakstein, E. - Anýž, J. - Hlinka, Jaroslav - Sieger, T. - Hrdlička, J. - Görnerová, N. - Höschl, C.
Relapse in Schizophrenia: Definitively not a Bolt from the Blue.
Neuroscience Letters. Roč. 669, 16 March (2018), s. 68-74. ISSN 0304-3940. E-ISSN 1872-7972
Grant - others:GA MZd(CZ) NT14387
Institutional support: RVO:67985807
Keywords : schizophrenia * early warning signs * relapse * prevention * telemedicine * information technology
OECD category: Psychiatry
Impact factor: 2.173, year: 2018

Background: Detailed study of the period before schizophrenic relapse when early warning signs (EWS) are present is crucial to effective pre-emptive strategies. Aims: To investigate the temporal properties of EWS self-reported weekly via a telemedicine system. Method: EWS history was obtained for 61 relapses resulting in hospitalization involving 51 patients with schizophrenia. Up to 20 weeks of EWS history per case were evaluated using a non-parametric bootstraptest and generalized mixed-effects model to test the significance and homogeneity of the findings. Results: A statistically significant increase in EWS sum score was detectable 5 weeks before hospitalization. However, analysis of EWS dynamics revealed a gradual, monotonic increase in EWS score across during the 8 weeks before a relapse. Conclusions: The findings - in contrast to earlier studies - suggest that relapse is preceded by a lengthy period during which pathophysiological processes unfold. These changes are reflected in subjective EWS.
Permanent Link: http://hdl.handle.net/11104/0270803