Carbonic anhydrase inhibitors and method of their production

0473217 - ÚMG 2017 RIV eng P - Patent Document
Brynda, Jiří - Cígler, P. - Gruner, B. - Řezáčová, Pavlína - Mader, Pavel - Šícha, V. - Bakardjiev, M. - Holub, J. - Džubák, P. - Hajdúch, M.
Carbonic anhydrase inhibitors and method of their production.
2016. Owner: Ústav organické chemie a viochemie AV ČR, v. v. i., Ústav molekulární genetiky AV ČR, v. v. i., Ústav anorganické chemie AV ČR, v. v. i., Univerzita Palackého v Olomouci. Date of the patent acceptance: 16.03.2016. Patent Number: EP2771015
Institutional support: RVO:68378050
Keywords : cancer enzyme * inhibition * carboranes
Subject RIV: EB - Genetics ; Molecular Biology
https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2771015A1&KC=A1&date=&FT=D&locale=en_EP#

The invention describes new derivatives of boron cluster compounds of general formula (I) and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. The invention also includes methods of synthesis and the use of the novel derivatives. The inhibitiors of human carbonic anhydrase IX of this invention can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
Permanent Link: http://hdl.handle.net/11104/0270374