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Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells
- 1.0473134 - BTÚ 2017 RIV GB eng J - Journal Article
Váňová, K. - Boukalová, Štěpána - Gbelcová, H. - Muchová, L. - Neužil, Jiří - Gürlich, R. - Ruml, T. - Vítek, L.
Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells.
Bmc Cancer. Roč. 16, May 12 (2016), č. článku 309. E-ISSN 1471-2407
R&D Projects: GA MZd NT14078; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : Heme * Heme oxygenase * Pancreatic cancer * Statins
Subject RIV: FD - Oncology ; Hematology
Impact factor: 3.288, year: 2016
Background: Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways. In healthy tissues, statins activate the heme oxygenase pathway, nevertheless the role of heme oxygenase in pancreatic cancer is still controversial. The aim of this study was to evaluate, whether anti-proliferative effects of statins in pancreatic cancer cells are mediated via the heme oxygenase pathway.
Permanent Link: http://hdl.handle.net/11104/0270305
Number of the records: 1