EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

0472836 - FGÚ 2017 RIV ME eng C - Conference Paper (international conference)
Pavelka, Stanislav
EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM.
RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH. Niš: RAD ASSOC, 2015 - (Ristić, G.), s. 471-474. ISBN 978-86-80300-01-6.
[International Conference on Radiation and Applications in Various Fields of Research (RAD) /3./. Budva (ME), 08.06.2015-12.06.2015]
Grant - others:AV ČR(CZ) SAV-15-03
Program: Bilaterální spolupráce
Institutional support: RVO:67985823
Keywords : antidepressant fluoxetine * radiometric enzyme assays * thyroid hormones
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition

In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. The elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.
Permanent Link: http://hdl.handle.net/11104/0270056