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RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS
- 1.0472832 - FGÚ 2017 RIV ME eng C - Conference Paper (international conference)
Pavelka, Stanislav
RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS.
RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH. Niš: RAD ASSOC, 2015 - (Ristić, G.), s. 463-466. ISBN 978-86-80300-01-6.
[International Conference on Radiation and Applications in Various Fields of Research (RAD) /3./. Budva (ME), 08.06.2015-12.06.2015]
Grant - others:AV ČR(CZ) SAV-15-03
Program: Bilaterální spolupráce
Institutional support: RVO:67985823
Keywords : bromide * perchlorate * thyroid hormones * radiometric determination * xenobiotics
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Recently, we have shown in the isolated rat thyroid glands marked effects of excessive exogenous bromide and perchlorate ions on the activity of thyroid peroxidase (TPO), the key enzyme in thyroid hormones (TH) metabolism. Here, we studied in more details effects of an enhanced bromide and/or perchlorate intake on various aspects of iodine metabolism and, consequently, on TH metabolism in the rat. With the use of several radioanalytical methods, including adapted radiometric determination of TPO enzyme activity, we confirmed and quantified the presumed thyrotoxic effects of xenobiotics bromide and perchlorate ions.
Permanent Link: http://hdl.handle.net/11104/0270050
Number of the records: 1