HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

0472044 - ÚMG 2017 RIV US eng J - Journal Article
Janečková, Lucie - Kolář, Michal - Švec, Jiří - Láníková, Lucie - Pospíchalová, Vendula - Baloghová, Nikol - Vojtěchová, Martina - Šloncová, Eva - Strnad, Hynek - Kořínek, Vladimír
HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy.
Translational Oncology. Roč. 9, č. 2 (2016), s. 99-107. ISSN 1944-7124. E-ISSN 1936-5233
R&D Projects: GA ČR GAP305/12/2347; GA MŠMT LO1419; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : direct target gene * cancer 1 hic1 * colorectal-cancer * breast-cancer * lung-cancer * tgf-beta * methylation * hypermethylation * subtypes * cells
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.025, year: 2016

Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
Permanent Link: http://hdl.handle.net/11104/0269388