Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells

0472015 - BFÚ 2017 RIV GB eng J - Journal Article
Štefančíková, Lenka - Lacombe, S. - Salado, D. - Porcel, E. - Pagáčová, Eva - Tillement, O. - Lux, F. - Depeš, Daniel - Kozubek, Stanislav - Falk, Martin
Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells.
Journal of Nanobiotechnology. Roč. 14, JUL2016 (2016), č. článku 63. E-ISSN 1477-3155
R&D Projects: GA ČR GBP302/12/G157
Institutional support: RVO:68081707
Keywords : induced genomic instability * high-resolution cytometry
Subject RIV: BO - Biophysics
Impact factor: 4.946, year: 2016

Background: Tumor targeting of radiotherapy represents a great challenge. The addition of multimodal nanoparticles, such as 3 nm gadolinium-based nanoparticles (GdBNs), has been proposed as a promising strategy to amplify the effects of radiation in tumors and improve diagnostics using the same agents. This singular property named theranostic is a unique advantage of GdBNs. It has been established that the amplification of radiation effects by GdBNs appears due to fast electronic processes. However, the influence of these nanoparticles on cells is not yet understood. In particular, it remains dubious how nanoparticles activated by ionizing radiation interact with cells and their constituents. A crucial question remains open of whether damage to the nucleus is necessary for the radiosensitization exerted by GdBNs (and other nanoparticles).
Permanent Link: http://hdl.handle.net/11104/0269368