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Decellularized Porcine Pericardium for Cardiovascular Tissue Engineering

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    0471889 - FGÚ 2017 RIV IT eng C - Conference Paper (international conference)
    Marková, Marie - Filová, Elena - Matějka, Roman - Trávníčková, Martina - Koňařík, M. - Pirk, J. - Bačáková, Lucie
    Decellularized Porcine Pericardium for Cardiovascular Tissue Engineering.
    CORONARY ARTERY DISEASE 2015. Bologna: Medimond, 2016, s. 13-16. ISBN 978-88-7587-729-3.
    [International Congress on Coronary Artery Disease /11./. Florence (IT), 29.11.2015-02.12.2015]
    R&D Projects: GA ČR(CZ) GAP108/12/1168; GA TA ČR(CZ) TA04011345; GA MŠk(CZ) ED1.1.00/02.0109; GA MZd(CZ) NV15-29153A
    Institutional support: RVO:67985823
    Keywords : decellularization * stem cells * pericardium
    Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

    Biological prostheses made of decellularized cross-linked bovine pericardium and porcine aortic heart valves or mechanical prostheses are used for transplantation of aortic heart valves. None of these prostheses contain autologous cells. The purpose of our study is to prepare decellularized porcine pericardium, which would be suitable for colonizing with both autologous stem cells and endothelial cells, and subsequently transplanted into a patient. For decellularization, we tested different solutions and time of exposure. Effectiveness of decellularization process was assessed by hematoxylin-eosin staining and Hoechst staining. Extracts of the decellularized pericardium were evaluated for biocompatibility using xCelligence method. Decellularized porcine pericardium seems to be a suitable scaffold for preparing bioartificial heart valves.
    Permanent Link: http://hdl.handle.net/11104/0269251

     
     
Number of the records: 1