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14-3-3 Proteins: A Family of Versatile Molecular Regulators
- 1.0471750 - FGÚ 2017 CZ eng J - Journal Article
Obšilová, Veronika - Šilhan, J. - Bouřa, Evžen - Teisinger, Jan - Obšil, Tomáš
14-3-3 Proteins: A Family of Versatile Molecular Regulators.
Physiological Research. Roč. 57, Suppl.3 (2008), S11-S21. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LC554; GA AV ČR(CZ) IAA501110801; GA AV ČR(CZ) KJB500110601
Institutional research plan: CEZ:AV0Z50110509
Keywords : 14-3-3 protein * forkhead transcription factor FOXO4 * tyrosine hydroxylase * conformation
Subject RIV: BO - Biophysics
Impact factor: 1.653, year: 2008
The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
Permanent Link: http://hdl.handle.net/11104/0269080
Number of the records: 1