Carbonic anhydrase inhibitors and method of their production

0471687 - ÚOCHB 2017 RIV eng P - Patent Document
Brynda, Jiří - Cígler, Petr - Grüner, Bohumír - Maloy Řezáčová, Pavlína - Mader, P. - Šícha, Václav - Bakardjiev, Mario - Holub, Josef - Džubák, P. - Hajdúch, M.
Carbonic anhydrase inhibitors and method of their production.
2016. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav molekulární genetiky AV ČR, v. v. i. - Ústav anorganické chemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 16.03.2016. Patent Number: EP2771015
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : cancer enzyme * inhibition * carboranes
Subject RIV: CE - Biochemistry; CA - Inorganic Chemistry (UACH-T)
https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2771015B1&KC=B1&FT=D&ND=5&date=20160316&DB=&locale=en_EP#

The invention describes new derivatives of boron cluster compounds of general formula (I) and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. The invention also includes methods of synthesis and the use of the novel derivatives. The inhibitiors of human carbonic anhydrase IX of this invention can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases. (Formula (I)).
Permanent Link: http://hdl.handle.net/11104/0269487