Understanding Enzymes: Function, Design, Engineering and Analysis

0469865 - ÚMCH 2017 RIV SG eng M - Monography Chapter
Dohnálek, Jan - McAuley, K. E. - Brzozowski, A. M. - Ostergaard, P. R. - Svendsen, A. - Wilson, K. S.
Stabilization of enzymes by metal binding: structures of two alkalophilic Bacillus subtilases and analysis of the second metal-binding site of the subtilase family.
Understanding Enzymes: Function, Design, Engineering and Analysis. Singapore: Pan Stanford Publishing Pte. Ltd., 2016 - (Svendsen, A.), s. 203-265. ISBN 978-981-4669-32-0
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61389013
Keywords : enzyme * structural biology * virology
Subject RIV: EB - Genetics ; Molecular Biology
http://www.panstanford.com/books/9789814669320.html

This Chapter (chapter 6), focuses on stabilization of enzymes by metal binding. The book containing 25 chapters and focuses on the understanding of enzyme function and optimization gained in the past decade, past enzyme function analysis, enzyme engineering, and growing insights from the simulation work and nanotechnology measurement of enzymes in action in vitro or in silico. The book also presents new insights into the mechanistic function and understanding of enzyme reactions, as well as touching upon structural characteristics, including X-ray and nuclear magnetic resonance (NMR) structural methods. A major focus of the book is enzyme molecules’ dependency on dynamic and biophysical environmental impacts on their function in ensembles as well as single molecules.
Permanent Link: http://hdl.handle.net/11104/0269271