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Nežádoucí metabolické účinky aripiprazolu v poly I:C modelu schizofrenie u potkana
- 1.0469307 - ÚPT 2017 RIV CZ eng C - Conference Paper (international conference)
Horská, K. - Rudá-Kučerová, J. - Dražanová, Eva - Pistovčáková, J. - Karpíšek, M. - Kotolová, H. - Demlová, R. - Kašpárek, T.
Nežádoucí metabolické účinky aripiprazolu v poly I:C modelu schizofrenie u potkana.
[Aripiprazole-induced adverse metabolic alterations in a polyI:C neurodevelopmental model of schizophrenia in rats.]
Psychiatrie. Supplementum 1. Vol. 21. Praha: Tigis, 2017, s. 53-54. ISSN 1211-7579.
[Česko-slovenská psychofarmakologická konference. Jeseník (CZ), 04.01.2017-08.01.2017]
Institutional support: RVO:68081731
Keywords : metabolic syndrome * aripiprazole * rat * poly I:C animal model
OECD category: Neurosciences (including psychophysiology
The aim of this study was to evaluate metabolic phenotype of poly I:C rat model and asses metabolic effects of chronic aripiprazole treatment with regard to complex neuroendocrine regulations of energy homeostasis. Altered lipid profile in poly I:C model was observed. Leptin and GLP-1 serum levels were significantly reduced, while ghrelin level was elevated. Our data indicate that dysregulation of adipose tissue endocrine function and gastrointestinal hormones is implicated in metabolic adverse effects of antipsychotics.
Permanent Link: http://hdl.handle.net/11104/0267114
Number of the records: 1