Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs for treatment of solid tumours

0469013 - ÚMCH 2017 RIV eng P - Patent Document
Etrych, Tomáš - Chytil, Petr - Strohalm, Jiří - Ulbrich, Karel - Říhová, Blanka
Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs for treatment of solid tumours.
2015. Owner: Ústav makromolekulární chemie AV ČR, v. v. i. - Mikrobiologický ústav AV ČR, v. v. i. Date of the patent acceptance: 22.12.2015. Patent Number: CA2783393
R&D Projects: GA AV ČR IAA400500806; GA AV ČR KAN200200651
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Keywords : polymer conjugates * doxorubicin * drug targeting
Subject RIV: CD - Macromolecular Chemistry; FR - Pharmacology ; Medidal Chemistry (MBU-M)
http://www.ic.gc.ca/opic-cipo/cpd/eng/patent/2783393/summary.html?type=number_search&tabs1Index=tabs1_1

The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
Permanent Link: http://hdl.handle.net/11104/0266915