Effect of Colloidal Silica on Rheological Properties of Common Pharmaceutical Excipients.

0468966 - ÚCHP 2017 RIV NL eng J - Journal Article
Majerová, D. - Kulaviak, Lukáš - Růžička, Marek - Štěpánek, F. - Zámostný, P.
Effect of Colloidal Silica on Rheological Properties of Common Pharmaceutical Excipients.
European Journal of Pharmaceutics and Biopharmaceutics. Roč. 106, SI (2016), s. 2-8. ISSN 0939-6411. E-ISSN 1873-3441.
[International Granulation Workshop /7./. Sheffield, 29.06.2015-03.07.2015]
R&D Projects: GA ČR(CZ) GA15-05534S
Institutional support: RVO:67985858
Keywords : powder flow * cohesion * glidants
Subject RIV: CI - Industrial Chemistry, Chemical Engineering
Impact factor: 4.159, year: 2016

In this work, rheological properties of four common excipients were studied by the FT4 Powder Rheometer, which was used for measuring the compressibility index by a piston and flow properties of the powders by a rotational shear cell. After an initial set of measurements, two excipients were chosen and mixed, in varying amounts, with anhydrous colloidal silicon dioxide (Aerosil 200) used as a glidant. The bulk (conditioned and compressed densities, dynamic (basic flow energy) and shear (friction coefficient, flow factor) properties were determined to find an optimum ratio of the glidant. Simultaneously, the particle size data were obtained using a low-angle laser light scattering (LALLS) system and scanning electron microscopy was performed in order to examine the relationship between the rheological properties and the inner structure of the materials. The optimum of flowability for the mixture composition was found, to correspond to empirical findings known from general literature. In addition the mechanism of colloidal silicone dioxide action to improve flowabitlity was suggested and the hypothesis was confirmed by independent test. New findings represent a progress towards future application of determining the optimum concentration of glidant from the basic characteristics of the powder in the pharmaceutical research and development.
Permanent Link: http://hdl.handle.net/11104/0266853