0468817 - BC 2017 RIV NL eng J - Journal Article
Zíková, Alena - Hampl, V. - Paris, Zdeněk - Týč, Jiří - Lukeš, Julius
Aerobic mitochondria of parasitic protists: diverse genomes and complex functions.
Molecular and Biochemical Parasitology. Roč. 209, 1-2 (2016), s. 46-57. ISSN 0166-6851. E-ISSN 1872-9428
R&D Projects: GA ČR GA15-21974S; GA MŠMT LL1205
Institutional support: RVO:60077344
Keywords : protists * mitochondrion * genomes * repliation * RNA editing * ribosomes * electron transport chain * iron-sulfur cluster * heme
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.536, year: 2016

In this review the main features of the mitochondria of aerobic parasitic protists are discussed. While the best characterized organelles are by far those of kinetoplastid flagellates and Plasmodium, we also consider amoebae Naegleria and Acanthamoeba, a ciliate Ichthyophthirius and related lineages. The simplistic view of the mitochondrion as just a power house of the cell has already been abandoned in multicellular organisms and available data indicate that this also does not apply for protists. We discuss in more details the following mitochondrial features: genomes, post-transcriptional processing, translation, biogenesis of iron-sulfur complexes, heme metabolism and the electron transport chain. Substantial differences in all these core mitochondrial features between lineages are compatible with the view that aerobic protists harbor organelles that are more complex and flexible than previously appreciated.
Permanent Link: http://hdl.handle.net/11104/0266634