Capillary electrophoresis with contactless conductivity detection for rapid determination of meldonium in urine

0467992 - ÚIACH 2017 RIV CZ eng C - Conference Paper (international conference)
Šlampová, Andrea - Kubáň, Pavel
Capillary electrophoresis with contactless conductivity detection for rapid determination of meldonium in urine.
CECE 2016. 13th International Interdisciplinary Meeting on Bioanalysis. Brno: Ústav analytické chemie AV ČR, v. v. i., 2016 - (Foret, F.; Křenková, J.; Drobníková, I.; Klepárník, K.), s. 234-236. ISBN 978-80-904959-4-4.
[CECE 2016. International Interdisciplinary Meeting on Bioanalysis /13./. Brno (CZ), 17.10.2016-19.10.2016]
R&D Projects: GA ČR(CZ) GA16-09135S
Institutional support: RVO:68081715
Keywords : meldonium * capillary electrophoresis-capacitively coupled contactless conductivity detection * urine
Subject RIV: CB - Analytical Chemistry, Separation

A simple, rapid and cheap capillary electrophoresis-capacitively coupled contactless
conductivity detection (CE-C4D) method for determination of meldonium (MEL) in
urine samples was developed. Sample pretreatment was minimized to dilution of urine
samples with DI water and MEL was determined by CE-C4D in background electrolyte
consisting of 2 M acetic acid (pH 2.3) in ng mL−1 to mg mL−1 concentration range.
Sample-to-sample analysis time was less than 4 min, limit of detection and
quantification was 0.015 and 0.05 μg mL−1, respectively, and the method showed
excellent linearity (r2 ≥ 0.9998), recovery (97.6–99.9%) and intraday as well as interday
repeatability (RSD ≤ 4.7%).
Permanent Link: http://hdl.handle.net/11104/0265921