Number of the records: 1
Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides
- 1.0466870 - ÚOCHB 2017 RIV GB eng J - Journal Article
Botha, Filip - Slavíčková, Michaela - Pohl, Radek - Hocek, Michal
Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides.
Organic & Biomolecular Chemistry. Roč. 14, č. 42 (2016), s. 10018-10022. ISSN 1477-0520. E-ISSN 1477-0539
R&D Projects: GA ČR GA14-04289S
Institutional support: RVO:61388963
Keywords : cross-link formation * unprotected nucleosides * photochemical control
Subject RIV: CC - Organic Chemistry
Impact factor: 3.564, year: 2016
http://pubs.rsc.org/en/content/articlepdf/2016/ob/c6ob01917j
The syntheses of 5-arylsulfanyl-or 5-arylselanylpyrimidine and 7-arylsulfanyl-or 7-arylselanyl-7-deazapurine nucleosides and nucleotides were developed by the Cu-mediated sulfanylations or selanylations of the corresponding 5-iodopyrimidine or 7-iodo-7-deazapurine nucleosides or nucleotides with diaryldisulfides or -diselenides. The reactions were also applicable for direct modifications of 2'-deoxycytidine triphosphate and the resulting 5-arylsulfanyl or 5-arylselanyl-dCTP served as substrates for the polymerase synthesis of modified DNA bearing arylsulfanyl or arylselanyl groups in the major groove.
Permanent Link: http://hdl.handle.net/11104/0265068
Number of the records: 1