Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates

0464721 - ÚVGZ 2017 ES eng C - Conference Paper (international conference)
Goněc, T. - Straník, J. - Pesko, M. - Kos, J. - Oravec, Michal - Kralova, K. - Jampílek, J.
Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates.
Proceedings of the 20th International Electronic Conference on Synthetic Organic Chemistry. Basilej: MDPI, 2016 - (Seijas,, J.; Pilar Vázquez Tato; Shu-Kun,, L.), b004
[International Electronic Conference on Synthetic Organic Chemistry /20./. Basel (ES), 01.11.2016-30.11.2016]
R&D Projects: GA MŠMT(CZ) LO1415; GA MŠMT(CZ) LM2015061
Institutional support: RVO:67179843
Keywords : Alkylcarbamates * Hydroxynaphthalene-carboxamides * PET inhibition * Spinach chloroplasts * Structure-activity relationships
Subject RIV: EH - Ecology, Behaviour

In this study, a series of eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates was prepared and characterized. The discussed compounds were prepared by microwave-assisted and conventional synthesis. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC50 values ranged from 0.233 to 0.487 mmol/L and the highest activity within the series of compounds was observed for 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl pentylcarbamate. The compounds were found to inhibit PET in photosystem II.
Permanent Link: http://hdl.handle.net/11104/0263502