Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer

0464251 - MBÚ 2017 RIV GR eng J - Journal Article
Kulda, V. - Topolčan, O. - Kučera, R. - Kripnerová, M. - Srbecká, K. - Hora, M. - Hes, O. - Klečka, J. - Babuška, V. - Rousárová, M. - Benson, Veronika - Pesta, M.
Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer.
Anticancer Research. Roč. 36, č. 7 (2016), s. 4787-4793. ISSN 0250-7005. E-ISSN 1791-7530
Institutional support: RVO:61388971
Keywords : Prostate cancer * TMPRSS2-ERG * PSA
Subject RIV: FD - Oncology ; Hematology
Impact factor: 1.937, year: 2016

Background/Aim: Current research of prostate cancer (PCa) offers a promising way of identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality of life as resections are associated with numerous side-effects. The aim of our study was to evaluate the relationship of TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), prostate cancer antigen 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy. Patients and Methods: The study group consisted of 108 patients who underwent radical prostatectomy. PSA was measured in peripheral blood collected preoperativelly. The expression of TMPRSS2-ERG transcript and the expression of miR-23b, miR-26a and miR-221 in formalin-fixed, paraffin-embedded (FFPE) tumor tissues was analyzed by reverse transcription (RT) real-time polymerase chain reaction (PCR).
Permanent Link: http://hdl.handle.net/11104/0263326